Description

Buy Hardcore Labs RAD140 (Testolone) – High-Purity SARM for Advanced Research

 Buy RAD140 Europe, Welcome to eupeptideshop.org, your trusted source for premium research peptides EU and Research Sarms. We are pleased to offer Hardcore Labs RAD140 (Testolone) , a high-purity selective androgen receptor modulator (SARM) sought after by the global scientific community.

RAD140, also known by its research name Testolone, is a nonsteroidal compound originally developed by Radius Health, Inc. It is currently under investigation for its tissue-specific anabolic activity, particularly regarding muscle wasting conditions and hormone-responsive cancer models .

For researchers in Germany looking for high purity peptides, laboratories in France investigating muscle metabolism, or institutions in the Netherlands studying neuroprotection, this compound offers a versatile profile for rigorous in vitro and in vivo studies.

When you choose to buy RAD140 from us, you are investing in pharmaceutical-grade material backed by full analytical data (HPLC/MS) to ensure the integrity of your experimental outcomes.

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Why Purchase RAD140 from eupeptideshop.org?

As a premier peptide supplier Spain and throughout the continent, we understand that your research demands consistency and purity. Here is why we are the preferred choice to buy RAD140 Europe:

• Verified Purity: Our Hardcore Labs RAD140 batch is tested for >98% purity via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS).

• EU-Based Stock: We ship rapidly from our climate-controlled facilities within the EU. No customs delays. No long waits.

• Compliant Labeling: All products are clearly labeled for laboratory research chemicals EU compliant use, adhering to strict handling guidelines.

• Analytical Support: Each purchase includes access to a Certificate of Analysis (COA) to verify the chemical structure and purity.

• Secure Packaging: Discreet and secure packaging ensures the stability of the compound upon arrival.

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Technical Data Sheet

For the researcher looking for laboratory peptides Netherlands or conducting studies in peptide synthesis Europe, the following specifications are critical for protocol design.

Chemical Nomenclature

• IUPAC Name: 2-Chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile

• Synonyms: Testolone, RAD-140, Vosilasarm, EP0062

• CAS Number: 1182367-47-0

Structural Information

• Molecular Formula: C20H16ClN5O2

• Molecular Weight: 393.83 g/mol

• Sequence Information: Not applicable (Small molecule SARM, not a peptide)

Purity and Quality Control

• Purity Specification: ≥ 98% (HPLC)

• Appearance: Neat (Crystalline solid)

• QC Release: Batch-specific COA available upon request.

Solubility and Reconstitution

Proper reconstitution is essential for accurate dosing in research.

• Solubility Profile:

  • DMSO: Soluble at ≥ 100 mg/mL (253.92 mM)

  • Ethanol: Limited solubility (test via serial dilution)

  • Water (H2O): < 0.1 mg/mL (Insoluble)

• Reconstitution Guidelines:

  1. Calculate the required volume of solvent (preferably DMSO for stock solutions) based on desired molar concentration.

  2. Allow the vial to reach room temperature.

  3. Aseptically add the solvent directly to the vial.

  4. Gently swirl to dissolve. Do not shake vigorously as this may denature the compound’s structure.

Stability and Storage

• Recommended Storage Conditions:

  • Powder Form: Store at -20°C. Under these conditions, the compound is stable for up to 3 years .

  • In-Solution: Prepare stock solutions in anhydrous DMSO. Aliquot to avoid repeated freeze-thaw cycles and store at -80°C for up to 6 months, or at -20°C for up to 1 month .

• Handling Protocols: Use appropriate personal protective equipment (gloves, lab coat, safety goggles). Conduct all preparations in a fume hood. Keep the container tightly sealed and protected from light and moisture.

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Known Research Applications (Citations)

Researchers purchasing research chemicals EU compliant products utilize RAD140 for a variety of investigative pathways. Below are documented areas of study derived from peer-reviewed literature.

1. Androgen Receptor Specificity & Muscle Research

RAD140 binds the Androgen Receptor (AR) with high affinity (Ki of 7 nM) and shows selectivity over other steroid hormone nuclear receptors . Preclinical models indicate it stimulates the levator ani muscle weight, suggesting anabolic activity, while demonstrating a unique profile in prostate tissue studies . It is frequently utilized in models of muscle wasting and sarcopenia.

2. Neuroprotective Effects

A pivotal 2014 study in Endocrinology demonstrated that RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. The research indicated that RAD140 was as effective as testosterone in reducing cell death induced by apoptotic insults in hippocampal neurons, acting through the MAPK signaling pathway . This opens avenues for research into neurodegenerative diseases.

3. Oncology Research (AR+/ER+ Breast Cancer)

RAD140 is under investigation for its distinct mechanism of action in oncology. A study published in Clinical Cancer Research (2017) showed that RAD140 inhibits the growth of Androgen Receptor-positive / Estrogen Receptor-positive (AR+/ER+) breast cancer models. The research highlighted that RAD140 acts as a potent AR agonist in breast cancer cells, leading to the repression of the ESR1 gene (which encodes ERα) .

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Safety Considerations and Regulatory Status

As a leading peptides for research France supplier, we prioritize safety and transparency.

• Not for Human Use: This product is strictly for in vitro and animal research purposes only. It is not for human consumption, and it is not a medicine, food supplement, or cosmetic.

• Regulatory Status: RAD140 (Testolone) is an investigational compound. It is not FDA or EMA approved. It is classified as a prohibited substance by the World Anti-Doping Agency (WADA) .

• Safety Data:

  • Toxicity: Standard precautions for research chemicals should be observed. Safety Data Sheet (SDS) available on request.

  • Handling: Avoid inhalation, ingestion, or direct skin contact. In case of contact, wash immediately with copious amounts of water.

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Frequently Asked Questions (FAQ)

This FAQ section is designed to help researchers make an informed decision when they buy RAD140 Europe.

1. What is the difference between RAD140 and other SARMs like Ligandrol or Ostarine?

While all are SARMs, RAD140 (Testolone) is often noted in literature for its high potency at the androgen receptor and its distinct neuroprotective profile observed in animal models . Unlike steroidal androgens, RAD140 does not undergo 5-alpha reduction or aromatization, which is a key selectivity factor in prostate research models . Your choice should depend on your specific research hypothesis.

2. What purity level can I expect when I buy RAD140 from your store?

We guarantee a purity of >98% as determined by HPLC. This high purity standard is essential for ensuring that your research results are attributable to the compound itself, not to impurities. We recommend reviewing the Certificate of Analysis (COA) provided with your shipment.

3. How should I store the Hardcore Labs RAD140 vial upon arrival?

Upon receiving your shipment of research peptides EU stock, store the powder immediately in a freezer at -20°C. If you prepare a stock solution (e.g., in DMSO), aliquot it into sterile vials and store at -20°C, avoiding repeated freeze-thaw cycles .

4. Is RAD140 suitable for breast cancer research?

Yes, there is significant interest in this area. Studies have investigated RAD140’s efficacy in AR+/ER+ breast cancer patient-derived xenografts (PDX). The mechanism involves activation of the androgen receptor leading to suppression of the estrogen receptor pathway, including the ESR1 gene .

5. Why is DMSO the recommended solvent and not water?

Based on solubility data from chemical databases, RAD140 is practically insoluble in water (<0.1 mg/mL) but highly soluble in DMSO . Using DMSO ensures the compound goes into solution completely, allowing for accurate molarity in your dosing protocols.

6. What are the documented in vivo stability findings?

Preclinical studies have shown that RAD140 has high metabolic stability. It exhibits a half-life (t1/2) greater than 2 hours in incubations with rat, monkey, and human microsomes, indicating it is not rapidly metabolized. It also demonstrated good oral bioavailability in animal models (27-75%) .

7. Do you ship to my country (e.g., Spain, Germany, Italy)?

Yes, as a dedicated peptide supplier Spain and throughout the continent, we ship to all EU member states. Our central EU location ensures fast delivery for laboratory peptides Netherlands and high purity peptides Germany orders.

8. Is my payment and order secure?

Absolutely. eupeptideshop.org utilizes industry-standard encryption to protect your data. We offer various secure payment methods tailored to EU customers.
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